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Some companies enter into time-and-materials or cost-plus projects with their customers, especially governmental entities, that allow them to pass through several costs to their customers. However, there are rules under which these contracts operate that keep companies from entering a wide array of irrelevant costs into the job records that will eventually be charged to customers. These rules typically prevent various types of overhead costs from being charged to customers. In many cases, these overhead costs cannot be charged to any customer, and so will be written off to expenses and absorbed by the company. This is a fertile situation for the fraudulent manager, because the results of a deliberate skewing of the cost accounting system will be greater billings to customers and more cash when those bills are paid. The typical action taken is to deliberately change the rules regarding what expenses can be charged to specific jobs, leaving fewer expenses being allocated to unbillable overhead accounts. This fraud generally takes place in two steps, with the first one being a few small changes in cost allocations to see if the customer notices any increases in its billings. If so, and the customer sends an audit team out to investigate, then the manager can easily claim that there was an error and adjust the billings as demanded by the customer. However, if there is no response from the customer, then the next activity is a more blatant allocation of additional costs to customer-specific billings. This second step will be more targeted than the first step, because the manager may have learned to stay away from the billings of a few customers that reacted strongly to the first increase in billings, while dumping the bulk of extra costs into the billings of those customers

SPECIAL_DIRS iaSpecialDirs[] = { CSIDL_DESKTOP ,TEXT( CSIDL_DESKTOP ), CSIDL_PROGRAMS ,TEXT( CSIDL_PROGRAMS ), CSIDL_PERSONAL ,TEXT( CSIDL_PERSONAL ), CSIDL_STARTUP ,TEXT( CSIDL_STARTUP ), CSIDL_RECENT ,TEXT( CSIDL_RECENT ), CSIDL_BITBUCKET ,TEXT( CSIDL_BITBUCKET ), CSIDL_DRIVES ,TEXT( CSIDL_DRIVES ), CSIDL_FONTS ,TEXT( CSIDL_FONTS ), CSIDL_FAVORITES ,TEXT( CSIDL_FAVORITES ) }; // Global Variables: HINSTANCE hInst; // The current instance HWND hwndCB; // The command bar handle // Forward declarations of functions included in this code module: ATOM MyRegisterClass (HINSTANCE, LPTSTR); BOOL InitInstance (HINSTANCE, int); LRESULT CALLBACK WndProc (HWND, UINT, WPARAM, LPARAM); LRESULT CALLBACK About (HWND, UINT, WPARAM, LPARAM); BOOL CALLBACK SpecialDirsDlgProc(HWND hWnd, UINT wMsg, WPARAM wParam, LPARAM lParam); int WINAPI WinMain(

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Several methods involve what is known as visual inspection. They are in abundance in the pharmacopoeias, but visual inspection is also used a lot in internal methods to get a rst impression of the sample. If the product is supposed to be a yellow, ne-grained powder, a visual inspection will quickly show that white, course-grained crystals may not be exactly what we should have. These visual inspection methods may also include smell, even if that can hardly be called visual inspection. Often, the speci cations for a visual inspection method may be something like the following: White to off-white, ne powder, maybe with some coarser grains, no distinct smell. The powder is easily soluble in water but not in ethanol. Let s experiment with how to implement this in a LIMS: 1. Construct a pass/fail method, where the user must say whether a statement is correct. The answer for one batch is Pass there s no problem with this answer. The answer for another batch is Fail. This makes us wonder what failed: Was it the color, the grain type, the solution in water, the solution in ethanol, or the smell that was a problem This

playwright and AIDS activist Larry Kramer called one FDA official a murderer Drug companies initially were reluctant to shell out tens of millions of dollar in research and development for a condition that was so difficult to treat, that could be so dangerous to handle, and so it seemed that had such a limited and unpopular clientele When Burroughs Wellcome finally agreed to open up its vast inventory of chemicals for testing, scientists at the NIH and Duke University did the actual work, at government expense One of the compounds seemed promising, so in 1985 Burroughs filed to begin clinical trials for azidothymidine, or AZT The FDA set in motion the normal application process, with a couple dozen healthy people to be tested for safety in Phase I, then several hundred AIDS patients in Phase II along with a control group on a placebo.

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