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See also the following section on Acute Heart Failure & Pulmonary Edema 1 Diuretic therapy Diuretics are the most effective means of providing symptomatic relief to patients with moderate to severe CHF Few patients with symptoms or signs of fluid retention can be optimally managed without a diuretic However, excessive diuresis can lead to electrolyte imbalance and neurohormonal activation A combination of a diuretic and an ACE inhibitor should be the initial treatment in most symptomatic patients When fluid retention is mild, thiazide diuretics or a similar type of agent (hydrochlorothiazide, 25 100 mg; metolazone, 25 5 mg; chlorthalidone, 25 50 mg; etc) may be sufficient These agents block sodium reabsorption in the cortical diluting segment at the terminal portion of the loop of Henle and in the proximal portion of the distal convoluted tubule The result is natriuresis and kaliuresis These agents also have weak carbonic anhydrase inhibitor activity, which results in proximal tubule inhibition of sodium reabsorption Thiazide or related diuretics often provide better control of hypertension than short-acting loop agents The thiazides are generally ineffective when the glomerular filtration rate falls below 30 40 mL/min, a not infrequent occurrence in patients with severe heart failure Metolazone maintains its efficacy down to a glomerular filtration rate of approximately 20 30 mL/min Adverse reactions include hypokalemia and intravascular volume depletion with resulting prerenal azotemia, skin rashes, neutropenia and thrombocytopenia, hyperglycemia, hyperuricemia, and hepatic dysfunction Patients with more severe heart failure should be treated with one of the loop diuretics These include furosemide (20 320 mg daily), bumetanide (1 8 mg daily), and torsemide (20 200 mg daily) These agents have a rapid onset and a relatively short duration of action In patients with preserved renal function, two or more doses are preferable to a single larger dose In acute situations or when gastrointestinal absorption is in doubt, they should be given intravenously The loop diuretics inhibit chloride reabsorption in the ascending limb of the loop of Henle, which results in natriuresis, kaliuresis, and metabolic alkalosis They are active even in severe renal insufficiency, but larger doses (up to 500 mg of furosemide or equivalent) may be required The major adverse reactions include intravascular volume depletion, prerenal azotemia, and hypotension Hypokalemia, particularly with accompanying digitalis therapy, is a major problem Less common side effects.

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In most patients with heart failure, clinical examination and noninvasive tests can determine LV size and function and valve function well enough to confirm the diagnosis Left heart catheterization may be helpful to define the presence and extent of CAD, although CT angiography may also be appropriate, especially when the likelihood of coronary disease is low Evaluation for coronary disease is particularly important when LV dysfunction may be partially reversible by revascularization The combination of angina or noninvasive evidence of significant myocardial ischemia with symptomatic heart failure is often an indication for coronary angiography if the patient is a potential candidate for revascularization Right heart catheterization may be useful to select and monitor therapy in patients refractory to standard therapy

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Drazner MH et al Prognostic importance of elevated jugular venous pressure and a third heart sound in patients with heart failure N Engl J Med 2001 Aug 23;345(8):574 81 [PMID: 11529211] Maisel AS et al Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure N Engl J Med 2002 Jul 18;347(3):161 7 [PMID: 12124404]

The major reversible causes of chronic heart failure include valvular lesions, myocardial ischemia, uncontrolled hyperten-

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